Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future

Felix Mahfoud^{1

2}, Roland E Schmieder³, Michel Azizi^{4

5

6}, Atul Pathak^{7

8}, Horst Sievert^{9

10}, Costas Tsioufis¹¹, Thomas Zeller¹², Stefan Bertog⁹, Peter J Blankestijn¹³, Michael Böhm¹, Michel Burnier¹⁴, Gilles Chatellier¹⁵, Isabelle Durand Zaleski^{16

17}, Sebastian Ewen¹, Guido Grassi^{18

19}, Michael Joner^{20

21}, Sverre E Kjeldsen^{16

22}, Melvin D Lobo²³, Chaim Lotan¹⁸, Thomas Felix Lüscher¹⁹, Gianfranco Parati²⁰, Patrick Rossignol²⁴, Luis Ruilope²⁵, Faisal Sharif²⁶, Evert van Leeuwen²⁷, Massimo Volpe²⁸, Stephan Windecker²⁹, Adam Witkowski³⁰, William Wijns^{31

32}

Affiliations

¹ Klinik für Innere Medizin III, Saarland University Hospital, Angiologie und Internistische Intensivmedizin, 66421 Homburg, Saar, Germany.
² Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.
⁴ Paris-Descartes University, Paris, France.
⁵ Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France.
⁶ INSERM, CIC1418, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), F-75015 Paris, France.
⁷ Department of Cardiovascular Medicine, Hypertension, Risk Factors and Heart Failure Unit, Clinique Pasteur, Avenue de Lombez, Toulouse, France.
⁸ INSERM 1048, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Toulouse, France.
⁹ CardioVascular Center (CVC), Seckbacher Landstraße, Frankfurt, Germany.
¹⁰ Anglia Ruskin University, Chelmsford, UK.
¹¹ 1st Department of Cardiology, National and Kapodistrian University of Athens, Greece.
¹² Klinik Kardiologie und Angiologie II, Universitaets-Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.
¹³ Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ Service of Nephrology and Hypertension, University Hospital, Lausanne, Switzerland.
¹⁵ Université Paris-Descartes, F-75006 Paris, France.
¹⁶ ECEVE, UMR 1123, AP HP URCEco Ile de France Hopital de l'Hotel Dieu, Paris, France.
¹⁷ Sante Publique Hopital Henri Mondor, Creteil, France.
¹⁸ Clinica Medica, Università Milano-Bicocca, Italy.
¹⁹ IRCCS Multimedica, Sesto San Giovanni, Milan, Italy.
²⁰ Deutsches Herzzentrum München, Klinik für Kardiologie, Germany.
²¹ Deutsches Zentrum für Herz-Kreislaufforschung e.V., Standort München, Germany.
²² University of Oslo, Institute for Clinical Medicine, Oslo, Norway.
²³ William Harvey Research Institute, Barts NIHR Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
²⁴ INSERM, Centre d'Investigations Cliniques Plurithématique 1433 & U1116, Université de Lorraine, CHRU de Nancy, FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
²⁵ Institute of Investigation imas12 and Hypertension Unit, Hospital 12 de Octubre; Department of Preventive Medicine and Public Health, Universidad Autonoma and Department of Postdoctoral Studies and Investigation, Universidad Europea de Madrid, Madrid, Spain.
²⁶ CURAM, Cardiovascular Research Centre (CVRC) and BioInnovate Ireland, National University of Ireland Galway, Ireland.
²⁷ Department IQ healthcare, section Ethics, Radboudumc, Nijmegen, The Netherlands.
²⁸ Cardiology, Department of Clinical and Molecular Medicine, University of Rome Sapienza, Rome and IRCCS Neuromed, Pozzilli, Italy.
²⁹ Department of Cardiology, Bern University Hospital, Bern, Switzerland.
³⁰ Department of Interventional Cardiology & Angiology, Institute of Cardiology, Warsaw, Poland.
³¹ The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway, Ireland.
³² Saolta University Healthcare Group, Galway, Ireland.

PMID: 28475773
PMCID: PMC5837218
DOI: 10.1093/eurheartj/ehx215

Review

Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future

Felix Mahfoud et al. Eur Heart J. 2017.

. 2017 Nov 21;38(44):3272-3281.

doi: 10.1093/eurheartj/ehx215.

Authors

Affiliations

¹ Klinik für Innere Medizin III, Saarland University Hospital, Angiologie und Internistische Intensivmedizin, 66421 Homburg, Saar, Germany.
² Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.
⁴ Paris-Descartes University, Paris, France.
⁵ Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France.
⁶ INSERM, CIC1418, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), F-75015 Paris, France.
⁷ Department of Cardiovascular Medicine, Hypertension, Risk Factors and Heart Failure Unit, Clinique Pasteur, Avenue de Lombez, Toulouse, France.
⁸ INSERM 1048, and FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Toulouse, France.
⁹ CardioVascular Center (CVC), Seckbacher Landstraße, Frankfurt, Germany.
¹⁰ Anglia Ruskin University, Chelmsford, UK.
¹¹ 1st Department of Cardiology, National and Kapodistrian University of Athens, Greece.
¹² Klinik Kardiologie und Angiologie II, Universitaets-Herzzentrum Freiburg-Bad Krozingen, Bad Krozingen, Germany.
¹³ Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁴ Service of Nephrology and Hypertension, University Hospital, Lausanne, Switzerland.
¹⁵ Université Paris-Descartes, F-75006 Paris, France.
¹⁶ ECEVE, UMR 1123, AP HP URCEco Ile de France Hopital de l'Hotel Dieu, Paris, France.
¹⁷ Sante Publique Hopital Henri Mondor, Creteil, France.
¹⁸ Clinica Medica, Università Milano-Bicocca, Italy.
¹⁹ IRCCS Multimedica, Sesto San Giovanni, Milan, Italy.
²⁰ Deutsches Herzzentrum München, Klinik für Kardiologie, Germany.
²¹ Deutsches Zentrum für Herz-Kreislaufforschung e.V., Standort München, Germany.
²² University of Oslo, Institute for Clinical Medicine, Oslo, Norway.
²³ William Harvey Research Institute, Barts NIHR Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, UK.
²⁴ INSERM, Centre d'Investigations Cliniques Plurithématique 1433 & U1116, Université de Lorraine, CHRU de Nancy, FCRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.
²⁵ Institute of Investigation imas12 and Hypertension Unit, Hospital 12 de Octubre; Department of Preventive Medicine and Public Health, Universidad Autonoma and Department of Postdoctoral Studies and Investigation, Universidad Europea de Madrid, Madrid, Spain.
²⁶ CURAM, Cardiovascular Research Centre (CVRC) and BioInnovate Ireland, National University of Ireland Galway, Ireland.
²⁷ Department IQ healthcare, section Ethics, Radboudumc, Nijmegen, The Netherlands.
²⁸ Cardiology, Department of Clinical and Molecular Medicine, University of Rome Sapienza, Rome and IRCCS Neuromed, Pozzilli, Italy.
²⁹ Department of Cardiology, Bern University Hospital, Bern, Switzerland.
³⁰ Department of Interventional Cardiology & Angiology, Institute of Cardiology, Warsaw, Poland.
³¹ The Lambe Institute for Translational Medicine and Curam, National University of Ireland, Galway, Ireland.
³² Saolta University Healthcare Group, Galway, Ireland.

PMID: 28475773
PMCID: PMC5837218
DOI: 10.1093/eurheartj/ehx215

Erratum in

Erratum to: 'Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future.
[No authors listed] [No authors listed] Eur Heart J. 2018 May 1;39(17):1534. doi: 10.1093/eurheartj/ehx290. Eur Heart J. 2018. PMID: 28575182 Free PMC article. No abstract available.

No abstract available

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Figures

**Take home figure**
Suggested flow chart for trial of renal denervation in hypertensive patients initially off drugs.

See this image and copyright information in PMC

References

1. Freis ED. Effects of treatment on morbidity in hypertension: results in patients with diastolic blood pressures averaging 115 through 129 mmHg. JAMA 1967;202:1028–1034. - PubMed
1. Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, Chen J, He J.. Global disparities of hypertension prevalence and control. Circulation 2016;134:441–450. - PMC - PubMed
1. Marshall IJ, Wolfe CDA, McKevitt C.. Lay perspectives on hypertension and drug adherence: systematic review of qualitative research. BMJ 2012;345:e3953.. - PMC - PubMed
1. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, Backer GD, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Burnier M, Ambrosioni E, Caufield M, Coca A, Olsen MH. et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Hear J 2013;34:2159–2219. - PubMed
1. Mahfoud F, Lüscher TF, Andersson B, Baumgartner I, Cifkova R, DiMario C, Doevendans P, Fagard R, Fajadet J, Komajda M, LeFèvre T, Lotan C, Sievert H, Volpe M, Widimsky P, Wijns W, Williams B, Windecker S, Witkowski A, Zeller T, Böhm M.. Expert consensus document from the European Society of Cardiology on catheter-based renal denervation. Eur Heart J 2013;34:2149–2157. - PubMed

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Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future

Affiliations

Proceedings from the 2nd European Clinical Consensus Conference for device-based therapies for hypertension: state of the art and considerations for the future

Authors

Affiliations

Erratum in

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Medical