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Comment
. 2017 May 4;20(5):575-577.
doi: 10.1016/j.stem.2017.04.008.

Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis

Jessie A Brown  1 , Markus Schober  2
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Joining Forces: Bmi1 Inhibition and Cisplatin Curb Squamous Carcinogenesis

Jessie A Brown et al. Cell Stem Cell. .
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Abstract

Head and neck squamous cell carcinomas (HNSCCs) are refractory to therapeutic interventions. Chen et al. (2017) show that mouse and human HNSCCs and their metastases depend on Bmi1-expressing cancer stem cells and AP1 signaling and that simultaneously inhibiting Bmi1 or AP1, combined with Cisplatin, reduces tumor growth effectively in preclinical models.

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