Eyeing the Fountain of Youth
- PMID: 28475881
- DOI: 10.1016/j.stem.2017.04.007
Eyeing the Fountain of Youth
Abstract
Stem cell-based disease modeling is an emerging technology for the mechanistic study and therapeutic screening of complex ocular pathologies. In this issue of Cell Stem Cell, Saini et al. (2017) show that iPSC-derived RPE cells from age-related macular degeneration patients express increased levels of pro-inflammatory factors that can be normalized by the anti-aging drug nicotinamide.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration.Cell Stem Cell. 2017 May 4;20(5):635-647.e7. doi: 10.1016/j.stem.2016.12.015. Epub 2017 Jan 26. Cell Stem Cell. 2017. PMID: 28132833 Free PMC article.
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