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. 2017 May 4;20(5):590-592.
doi: 10.1016/j.stem.2017.03.025.

Hematopoiesis: Reconciling Historic Controversies about the Niche

Ninib Baryawno  1 , Nicolas Severe  1 , David T Scadden  2
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Free article

Hematopoiesis: Reconciling Historic Controversies about the Niche

Ninib Baryawno et al. Cell Stem Cell. .
Free article

Abstract

The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.

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