Comment
doi: 10.1016/j.cell.2017.04.030.
Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair
Affiliations
- PMID: 28475887
- DOI: 10.1016/j.cell.2017.04.030
Item in Clipboard
Comment
Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair
Cell.
.
Free article
Abstract
Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
-
Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.Cell. 2017 May 4;169(4):636-650.e14. doi: 10.1016/j.cell.2017.03.042. Epub 2017 Apr 20. Cell. 2017. PMID: 28434617 Free PMC article.
Similar articles
-
Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.Cell. 2017 May 4;169(4):636-650.e14. doi: 10.1016/j.cell.2017.03.042. Epub 2017 Apr 20. Cell. 2017. PMID: 28434617 Free PMC article.
-
Breathing life into the lung stem cell field.Cell Stem Cell. 2009 Jun 5;4(6):468-9. doi: 10.1016/j.stem.2009.05.012. Cell Stem Cell. 2009. PMID: 19497272
-
Exploring the role of stem cells in cutaneous wound healing.Exp Dermatol. 2009 Nov;18(11):921-33. doi: 10.1111/j.1600-0625.2009.00942.x. Epub 2009 Aug 27. Exp Dermatol. 2009. PMID: 19719838 Review.
-
Using stem cells in skin regeneration: possibilities and reality.Stem Cells Dev. 2012 May 20;21(8):1201-14. doi: 10.1089/scd.2011.0539. Epub 2012 Feb 7. Stem Cells Dev. 2012. PMID: 22188597 Review.
-
In search of a stem cell hierarchy in the human breast and its relevance to breast cancer evolution.APMIS. 2005 Nov-Dec;113(11-12):903-21. doi: 10.1111/j.1600-0463.2005.apm_344.x. APMIS. 2005. PMID: 16480457 Review.
Cited by
-
DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.J Cell Mol Med. 2019 Jan;23(1):512-521. doi: 10.1111/jcmm.13954. Epub 2018 Nov 18. J Cell Mol Med. 2019. PMID: 30450766 Free PMC article.
-
Into the breach: how cells cope with wounds.Open Biol. 2018 Oct 3;8(10):180135. doi: 10.1098/rsob.180135. Open Biol. 2018. PMID: 30282661 Free PMC article. Review.
-
Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation.Pharmaceutics. 2021 Sep 14;13(9):1469. doi: 10.3390/pharmaceutics13091469. Pharmaceutics. 2021. PMID: 34575545 Free PMC article.
-
Phytochemical analysis and in vitro cytostatic potential of ethnopharmacological important medicinal plants.Toxicol Rep. 2020 Feb 25;7:443-452. doi: 10.1016/j.toxrep.2020.02.016. eCollection 2020. Toxicol Rep. 2020. PMID: 32181145 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
