Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair

Samuel P Rowbotham¹, Carla F Kim²

Affiliations

¹ Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.

PMID: 28475887
DOI: 10.1016/j.cell.2017.04.030

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Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair

Samuel P Rowbotham et al. Cell. 2017.

Free article

. 2017 May 4;169(4):563-565.

doi: 10.1016/j.cell.2017.04.030.

Authors

Samuel P Rowbotham¹, Carla F Kim²

Affiliations

¹ Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
² Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.

PMID: 28475887
DOI: 10.1016/j.cell.2017.04.030

Abstract

Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.

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Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.
Ge Y, Gomez NC, Adam RC, Nikolova M, Yang H, Verma A, Lu CP, Polak L, Yuan S, Elemento O, Fuchs E. Ge Y, et al. Cell. 2017 May 4;169(4):636-650.e14. doi: 10.1016/j.cell.2017.03.042. Epub 2017 Apr 20. Cell. 2017. PMID: 28434617 Free PMC article.

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Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair

Affiliations

Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair

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