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Comment
. 2017 May 4;169(4):567-569.
doi: 10.1016/j.cell.2017.04.017.

Heavy Metal Enlightens Tumor Immunity

Jonathan H Chen  1 , Karin Pelka  2 , Nir Hacohen  3
Affiliations
Comment

Heavy Metal Enlightens Tumor Immunity

Jonathan H Chen et al. Cell. .

Abstract

A deep understanding of the immune landscape in human cancer is essential for guiding the development of immunotherapy to benefit more patients with long-lasting efficacy. Now, two studies from Lavin et al. and Chevrier et al. employ mass cytometry to study immune infiltrates in lung adenocarcinoma and clear cell renal cell carcinoma, respectively.

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Figures

Figure 1.
Figure 1.. Deconstructing a Human Tumor
Cells in human tumors are isolated and subjected to single-cell profiling, such as mass cytometry or single-cell RNA sequencing. Cells are then classified into clusters that represent distinct cell types and states, which can be correlated with clinical outcome or other variables. Functional studies are carried out on cells isolated based on markers identified by single-cell profiling.
See this image and copyright information in PMC

Comment on

  • An Immune Atlas of Clear Cell Renal Cell Carcinoma.
    Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B. Chevrier S, et al. Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016. Cell. 2017. PMID: 28475899 Free PMC article.
  • Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses.
    Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, Meinhof K, Chow A, Kim-Shulze S, Wolf A, Medaglia C, Li H, Rytlewski JA, Emerson RO, Solovyov A, Greenbaum BD, Sanders C, Vignali M, Beasley MB, Flores R, Gnjatic S, Pe'er D, Rahman A, Amit I, Merad M. Lavin Y, et al. Cell. 2017 May 4;169(4):750-765.e17. doi: 10.1016/j.cell.2017.04.014. Cell. 2017. PMID: 28475900 Free PMC article.

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