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. 1988 Oct;32(10):1595-7.
doi: 10.1128/AAC.32.10.1595.

Itraconazole pharmacokinetics in patients with renal dysfunction

J Boelaert  1 , M Schurgers, E Matthys, R Daneels, A van Peer, K De Beule, R Woestenborghs, J Heykants
Affiliations

Itraconazole pharmacokinetics in patients with renal dysfunction

J Boelaert et al. Antimicrob Agents Chemother. 1988 Oct.

Abstract

The single-dose pharmacokinetics of 200 mg of oral itraconazole were studied in seven uremic patients, seven patients treated by hemodialysis, and five patients treated by continuous ambulatory peritoneal dialysis. Plasma concentration-versus-time profiles showed wide intersubject variation. This study could not demonstrate any significant effect of renal dysfunction and hemodialysis or continuous ambulatory peritoneal dialysis treatment upon the pharmacokinetics of itraconazole, and firm conclusions concerning dosing in such patients should await confirmation of our data in a larger patient population.

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References

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    1. Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S43-6 - PubMed
    1. Antimicrob Agents Chemother. 1988 Sep;32(9):1310-3 - PubMed
    1. Antimicrob Agents Chemother. 1988 Jan;32(1):1-8 - PubMed

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