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Meta-Analysis
. 2017 May 5;6(5):e004896.
doi: 10.1161/JAHA.116.004896.

Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis

Ting-Ting Wu  1 , Yuan Chen  1 , Yun Zhou  1 , Dilare Adi  1 , Ying-Ying Zheng  1 , Fen Liu  2 , Yi-Tong Ma  1 , Xiang Xie  3
Affiliations
Meta-Analysis

Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis

Ting-Ting Wu et al. J Am Heart Assoc. .

Abstract

Background: The aim of the present study was to estimate the impact of dehydroepiandrosterone sulfate (DHEAS) on the prognosis of patients with cardiovascular disease by performing a systematic review and meta-analysis.

Methods and results: The Embase, PubMed, Web of Science, CNKI, and WanFang databases were searched up to September 5, 2016, to identify eligible studies. The quality of each study was assessed using the Newcastle-Ottawa Scale. The association between DHEAS, either on admission or at discharge, and cardiovascular disease outcomes were reviewed. The overall risk ratio for the effect of DHEAS on all-cause mortality and fatal and nonfatal cardiovascular events was pooled using a fixed-effects or a random-effects model. The publication bias was evaluated using funnel plots. Twenty-five studies were included for systematic review. The follow-up duration ranged from 1 to 19 years. Eighteen studies were included in the meta-analysis. We found that lower DHEAS levels indicated a significant increased risk for all-cause mortality (risk ratio, 1.47; 95% CI, 1.38-1.56 [P<0.00001]), fatal cardiovascular event (risk ratio, 1.58; 95% CI, 1.30-1.91 [P<0.00001]), and nonfatal cardiovascular event (risk ratio, 1.42; 95% CI, 1.24-1.62 [P<0.0001]) in patients with cardiovascular disease.

Conclusions: Patients with cardiovascular disease who have lower DHEAS levels may have poorer prognosis than those with higher DHEAS levels.

Keywords: cardiovascular disease; dehydroepiandrosterone sulfate; meta‐analysis; prognosis; sex hormones; systematic review.

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Figures

Figure 1
Figure 1
The flowchart of article inclusion. CVD indicates cardiovascular disease.
Figure 2
Figure 2
The relationship between dehydroepiandrosterone sulfate and all‐cause mortality.
Figure 3
Figure 3
The relationship between dehydroepiandrosterone sulfate and fatal cardiovascular events.
Figure 4
Figure 4
The relationship between dehydroepiandrosterone sulfate and nonfatal cardiovascular events.
Figure 5
Figure 5
Subgroup analysis of the relationship between dehydroepiandrosterone sulfate and prognosis of cardiovascular (CV) disease. ACM indicates all‐cause mortality.
Figure 6
Figure 6
Funnel plots for publication bias test. A, All‐cause mortality; (B) fatal cardiovascular events; (C) nonfatal cardiovascular events.
See this image and copyright information in PMC

References

    1. Regelson W, Kalimi M. Dehydroepiandrosterone (DHEA)—the multifunctional steroid. II. Effects on the CNS, cell proliferation, metabolic and vascular, clinical and other effects. Mechanism of action? Ann N Y Acad Sci. 1994;719:564–575. - PubMed
    1. Labrie F. Intracrinology. Mol Cell Endocrinol. 1991;78:C113–C118. - PubMed
    1. Zwain IH, Yen SS. Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology. 1999;140:880–887. - PubMed
    1. Cox JL, Chang Y, Ramaraj P. In‐vitro determination of biological and anabolic functions of weak androgen dehydroepiandrosterone (DHEA) using a variety of cell lines. Open J Endocr Metab Dis. 2015;5:105–116.
    1. Labrie F. DHEA, important source of sex steroids in men and even more in women. Prog Brain Res. 2010;182:97–148. - PubMed

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