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Review
. 2017 Jul 18;8(29):48460-48470.
doi: 10.18632/oncotarget.17223.

Global scientific trends on exosome research during 2007-2016: a bibliometric analysis

Yiran Wang  1   2 , Qijin Wang  3 , Xianzhao Wei  4 , Jie Shao  4 , Jian Zhao  4 , Zicheng Zhang  2 , Ziqiang Chen  4 , Yushu Bai  4 , Ning Wang  1 , Yajie Wang  1 , Ming Li  4 , Xiao Zhai  4
Affiliations
Review

Global scientific trends on exosome research during 2007-2016: a bibliometric analysis

Yiran Wang et al. Oncotarget. .

Abstract

Background: Exosomes are small vesicles of endosomal origin, and they can be used for the diagnosis and the treatment. However, limited data were for the evaluation of the trend of exosome researches. This study aims to investigate the trend of exosome researches and compare the contribution of research from different regions, organizations and authors.

Methods: Exosome related publications from 2007 to 2016 were retrieved from the Web of Science database. Excel, GraphPad Prism 5 and VOSviewer software were used to analyze the research trend.

Results: A total of 1852 papers were identified and were cited 62967 times. The United States accounted for 38.8% of the articles, 42.0% of the citations, and the highest H-index (76). China ranked the second in the number of articles, but the sixth in citation frequency (4337) and the fourth in H-index (36). The journals, PLoS ONE and J Biol Chem had the highest number of publications. The author, Gabrielsson S., has published the most papers in this field (22). The keyword "ribonucleic acid" was mentioned the most at 746 times, and the words, "stem cell", "drug resistance" and "monocyte cell factor" were the latest hotspots appeared around 2015.

Conclusion: Literature growth related to exosome is expanding rapidly. The quality of the articles from China still requires improvement. Recent studies focus on the relationship with tumor, and "stem cell", "drug resistance" and "michigan cancer foundation-7" may be the newest topics that should be closely followed in exosome research.

Keywords: H-index; VOSviewer; bibliometric; citation; exosome.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. Flow diagram of exosome researches inclusion
Figure 2
Figure 2. Contributive characteristics on exosome researches
(A) The number of worldwide and the top 3 countries publications on exosome researches and the line of relative research interest; (B) The distribution, citation frequency (×0.2) and H-index data (×10) of publications in the top 10 countries; (C) The number of publications on exosome researches from the top 15 contribution institutions; (D) The number of publications in the top 15 popular journals on exosome researches.
Figure 3
Figure 3. The model fitting curves of growth trends of exosome publications
(A) Global; (B) the United States; (C) China; (D) Germany.
Figure 4
Figure 4. The analysis of key words
(A) Mapping on key words of exosome, the keywords were divided into four clusters according to different colors generated by default: Clinical Study (right in red), interaction related study (up in green), immunity related study (left in blue) and tumor related study (down in yellow). A large size of a circle represents the keyword appears at a high frequency; (B) Distribution of key words according to when they appeared for the average time, key words in blue presented earlier than those in yellow or red. Two terms are defined to co-occur if they both occur on the same line in the corpus file. In general, the smaller the distance between two terms, the larger the number of co-occurrences of the terms.
See this image and copyright information in PMC

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