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Comparative Study
. 1988 Oct 31;156(2):1046-53.
doi: 10.1016/s0006-291x(88)80950-1.

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

R Vince  1 , M Hua, J Brownell, S Daluge, F C Lee, W M Shannon, G C Lavelle, J Qualls, O S Weislow, R Kiser, et al.
Affiliations
Comparative Study

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

R Vince et al. Biochem Biophys Res Commun. .

Abstract

Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

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