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Review
. 2017 Jun;24(18):15254-15259.
doi: 10.1007/s11356-017-9105-3. Epub 2017 May 5.

Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

Daniel Araki Ribeiro  1   2   3 , Veronica Quispe Yujra  4 , Victor Hugo Pereira da Silva  5 , Samuel Rangel Claudio  5 , Debora Estadella  5 , Milena de Barros Viana  5 , Celina Tizuko Fujiyama Oshima  4
Affiliations
Review

Putative mechanisms of genotoxicity induced by fluoride: a comprehensive review

Daniel Araki Ribeiro et al. Environ Sci Pollut Res Int. 2017 Jun.

Abstract

Genotoxicity is the ability of an agent to produce damage on the DNA molecule. Considering the strong evidence for a relationship between genetic damage and carcinogenesis, to elucidate the putative mechanisms of genotoxicity induced by fluoride are important to measure the degree of risk involved to human populations. The purpose of this article is to provide a comprehensive review on genotoxicity induced by fluoride on the basis of its mechanisms of action. In the last 10 years, all published data showed some evidence related to genotoxicity, which is due to mitochondrial disruption, oxidative stress, and cell cycle disturbances. However, this is an area that still requires a lot of investigation since the published data are not sufficient for clarifying the genotoxicity induced by fluoride. Certainly, the new information will be added to those already established for regulatory purposes as a safe way to promote oral healthcare and prevent oral carcinogenesis.

Keywords: DNA damage; Fluoride; Genotoxicity; In vitro studies; In vivo studies.

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