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Review
. 2017 Jun:35:85-96.
doi: 10.1016/j.cytogfr.2017.04.002. Epub 2017 Apr 23.

Glucocorticoid resistance as a major drive in sepsis pathology

Karen Dendoncker  1 , Claude Libert  2
Affiliations
Review

Glucocorticoid resistance as a major drive in sepsis pathology

Karen Dendoncker et al. Cytokine Growth Factor Rev. 2017 Jun.

Abstract

Sepsis is an acute systemic inflammatory disease. Glucocorticoids (GCs), which function by binding to the GC receptor GR have very powerful anti-inflammatory activities, yet they are hardly useful in sepsis. We can thus consider sepsis as a GC resistant disease. We here review the literature which has investigated this GC resistance, and summarize the mechanisms of GC resistance that have been observed in other diseases and in experimental models. We also discuss the importance of GC resistance in sepsis, in terms of the contribution of this phenomenon to the pathogenesis of sepsis.

Keywords: Glucocorticoid resistance; Inflammation; Metabolism; Sepsis.

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