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Comparative Study
. 1988 Nov 21;240(1-2):127-32.
doi: 10.1016/0014-5793(88)80353-3.

Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

A B Van Kuilenburg  1 , A O Muijsers, H Demol, H L Dekker, J J Van Beeumen
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Free article
Comparative Study

Human heart cytochrome c oxidase subunit VIII. Purification and determination of the complete amino acid sequence

A B Van Kuilenburg et al. FEBS Lett. .
Free article

Abstract

Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a 'liver-type' subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals.

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