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Case Reports
. 2017 Jan-Apr;21(1):136-139.
doi: 10.4103/jomfp.JOMFP_122_15.

Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature

Rajani Korlepara  1 , Venkateswara Rao Guttikonda  1 , Jayakiran Madala  1 , Sravya Taneeru  1
Affiliations
Case Reports

Inflammatory myofibroblastic tumor of mandible: A rare case report and review of literature

Rajani Korlepara et al. J Oral Maxillofac Pathol. 2017 Jan-Apr.

Abstract

Inflammatory pseudotumor is a term given to different neoplastic and nonneoplastic entities that have a common histological appearance, which comprises spindle cell proliferation with a prominent chronic inflammatory cell infiltrate. Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion with distinctive clinical, pathological and molecular features and is considered to be pseudotumor for the past two decades due to its appearance. IMT is an intermediate soft tissue tumor which was first observed in lungs. It was named as IMT because it mimics a malignant neoplasm clinically, radiologically and histopathologically. The most common sites are lungs, liver and gastrointestinal tract. IMT in head and neck region is exceptionally rare and the sites reported include gingiva, tongue, hard palate, mandible, buccal mucosa and submandibular salivary gland. Till now, 8 cases of intramandibular IMT were reported. Here, we report an additional case of intramandibular IMT in a 20-year-old male patient.

Keywords: Anaplastic lymphoma kinase; myofibroblasts; spindle cells.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Extraoral picture revealing facial asymmetry on the left side
Figure 2
Figure 2
Intraoral picture revealing restricted mouth opening
Figure 3
Figure 3
(a and b) Orthopantomograph and computed tomography scan revealing radiolucency at the left ramus region
Figure 4
Figure 4
Excision of the tumor
Figure 5
Figure 5
Histopathology revealing fascicles of elongated spindle cells admixed with dense lymphocytes (a) spindle cells are plump ovoid to tapering hyperchromatic nuclei with mild nuclear atypia (b)
Figure 6
Figure 6
Immunohistochemistry revealing positivity for vimentin (a), smooth muscle actin (b), anaplastic lymphoma kinase (c) and negativity for s-100 (d)
See this image and copyright information in PMC

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