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Case Reports
. 2017 Jan-Mar;10(1):58-60.
doi: 10.4103/jhrs.JHRS_77_16.

Premature Ovarian Failure - An Unusual Manifestation of Systemic Sclerosis

Aruna Nigam  1 , Anupam Prakash  2 , Shikha Sharma  2 , Narendra Kumar  2
Affiliations
Case Reports

Premature Ovarian Failure - An Unusual Manifestation of Systemic Sclerosis

Aruna Nigam et al. J Hum Reprod Sci. 2017 Jan-Mar.

Abstract

A 31-year-old woman presented with secondary amenorrhoea and inability to conceive, which was of 3 years duration. She had Raynaud's phenomenon for 16 years, primary hypothyroidism for 5 years, digital ulcers for 4 years and skin tightening for 2 years. She had an expressionless face, with loss of wrinkles and restriction of the mouth opening along with flexion contractures of the hands and the terminal digit resorptions. Investigations showed Antinuclear antibodies (ANA) and anti-Scl 70 positivity confirming the presence of systemic sclerosis (SSc). The Follicle Stimulating Hormone (FSH) level was elevated, the ovarian follicles were absent, and the endometrial thickness was reduced confirming premature ovarian failure (POF). POF causing infertility and secondary amenorrhoea in SSc is an unusual manifestation; moreover, POF occured without the involvement of other internal organs.

Keywords: Amenorrhoea; infertility; menopause; premature ovarian failure; scleroderma; systemic sclerosis.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
An expressionless face, a taut and shiny skin, loss of wrinkles, with a reduced oral aperture and a pinched beak-like nose
Figure 2
Figure 2
Thickened, fixed flexion contracture of the fingers of the upper limbs
Figure 3
Figure 3
Amputation of the 2nd digit of the left lower limb
See this image and copyright information in PMC

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