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Case Reports
. 2017 Apr-Jun;8(2):281-283.
doi: 10.4103/0976-3147.203828.

Mild Encephalitis with a Reversible Splenial Lesion: A Clinical Benign Condition, often Underrecognized - Clinical Case and Literature Review

Sandro Zambito Marsala  1 , Eleonora Antichi  2 , Michele Pistacchi  3 , Manuela Gioulis  1 , Rosa Maria Candeago  2 , Roberta Taranto Montemurro  2 , Manrico Gentile  1 , Paolo D'Andrea  2 , Franco Ferracci  1
Affiliations
Case Reports

Mild Encephalitis with a Reversible Splenial Lesion: A Clinical Benign Condition, often Underrecognized - Clinical Case and Literature Review

Sandro Zambito Marsala et al. J Neurosci Rural Pract. 2017 Apr-Jun.

Abstract

Mild encephalitis with reversible lesion in the splenium is a clinicoradiological syndrome characterized by a variegated symptomatology with a solitary mass in the central portion of the splenium of the corpus callosum. Complete spontaneous resolution is the hallmark of this syndrome, though its pathogenesis is still unknown. We describe the clinical picture of a 51-year-old woman who developed a partial sensitive seizure, with MRI evidence of a lesion localized in the posterior portion of the corpus callosum. The patient made a full recovery thanks to the administration of antiepileptic drugs. Acquiring knowledge of this syndrome, in the wide diagnostic panel which includes vertebrobasilar diseases besides the broad range of metabolic and electrolyte disorders, is crucial to a prompt clinical diagnosis and in establishing a reliable prognosis at an early stage.

Keywords: Clinicoradiological syndrome; mild encephalitis; mild encephalitis with reversible lesion in the splenium.

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Conflict of interest statement

The authors declared that they acted in accordance with ethical standards laid in the 1964 Declaration of Helsinki.

Figures

Figure 1
Figure 1
MRI shows the lesion of 15 mm in the posterior portion of the corpus callosum on T2-immaging (a). Flair (b). diffusion weighted imaging (c and d). T1-immaging (e and f). and MRI-spectroscopy (g)
Figure 2
Figure 2
Follow-up brain images
See this image and copyright information in PMC

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