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Review
. 2017 Apr;8(2):229-242.
doi: 10.21037/jgo.2017.03.14.

Viral hepatitis and hepatocellular carcinoma: etiology and management

Philippe J Zamor  1 , Andrew S deLemos  1 , Mark W Russo  1
Affiliations
Review

Viral hepatitis and hepatocellular carcinoma: etiology and management

Philippe J Zamor et al. J Gastrointest Oncol. 2017 Apr.

Abstract

Chronic hepatitis B virus (HBV) and chronic hepatitis C virus (HCV) are associated with hepatic fibrosis and development of hepatocellular carcinoma (HCC). There are differences and variation with the incidence of HCC worldwide. Additionally, HCC develops via different pathways with these viral hepatitides. This review outlines the various mechanisms and pathophysiology that contributes to this process. There will also be a review on the recommended screening for HCC. Treatment considerations, which are different for these viruses, will be outlined in this review.

Keywords: Hepatocellular carcinoma (HCC); chronic hepatitis B; chronic hepatitis C; cirrhosis; sustained virologic response (SVR).

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Conflict of interest statement

Conflicts of Interest: Dr. Russo: speakers bureau for Gilead (HBV and HCV); bureau: (HCV)Gilead, Merck and AbbVie, (HBV) Gilead; Bayer (hepatocellular). Dr. Zamor: speakers bureau for Gilead (HCV); (HCV)Gilead, Merck and AbbVie. Dr. deLemos has no conflicts of interest to declare.

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