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Case Reports
. 2017:2017:4691325.
doi: 10.1155/2017/4691325. Epub 2017 Apr 5.

Life-Threatening Hemopericardium Associated with Rivaroxaban

Affiliations
Case Reports

Life-Threatening Hemopericardium Associated with Rivaroxaban

Sijan Basnet et al. Case Rep Cardiol. 2017.

Abstract

Rivaroxaban is a novel oral anticoagulant used in the treatment of venous thromboembolism. The use of this medication has expanded over the recent years with resultant expansion of side effect profile. We present a case of a 56-year-old female who presented with shortness of breath and chest pain 12 weeks after starting rivaroxaban for left upper extremity deep vein thrombosis. She was later diagnosed with spontaneous hemopericardium requiring pericardial fluid drainage. Rarer side effects like this will be encountered more often with the increasing use of novel oral anticoagulants. The clinicians should be cognizant of this entity among patients with shortness of breath and chest pain for timely diagnosis and intervention.

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Figures

Figure 1
Figure 1
CT scan transverse view with hyperdense pericardial effusion.
Figure 2
Figure 2
Echocardiography with pericardial effusion.

References

    1. Full prescribing information, January 2017, http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/202439s017lbl.pdf.
    1. Shivamurthy P., Brar N., Therrien M. L. Isolated hemopericardium associated with rivaroxaban: first case report. Pharmacotherapy. 2014;34(9):e169–e172. doi: 10.1002/phar.1474. - DOI - PubMed
    1. Menendez D., Michel J. Hemopericardium with tamponade following rivaroxaban administration and its attenuation by CYP3A4 inhibitors. Proceedings (Baylor University. Medical Center) 2016;29(4):414–415. - PMC - PubMed
    1. Xu B., MacIsaac A. Life-threatening haemorrhagic pericarditis associated with rivaroxaban. International Journal of Cardiology. 2014;174(2):e75–e76. doi: 10.1016/j.ijcard.2014.04.151. - DOI - PubMed
    1. Phillips M. F., Harper P. S. Cardiac disease in myotonic dystrophy. Cardiovascular Research. 1997;33(1):13–22. doi: 10.1016/S0008-6363(96)00163-0. - DOI - PubMed

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