COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE

Abstract

Background: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine induced amnesic animals.

Materials and methods: The anti-amnesic activity of the ethyl acetate extracts of Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated.

Results: The ethyl acetate extract of Morinda lucida and Peltophorum pterocarpum ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated.

Conclusion: Morinda lucida and Peltophorum pterocarpum showed considerable enhancement of cognition in scopolamine induced amnesic mice.

Keywords: Hippocampus; Morinda lucida; Morris water maze; Peltophorum pterocarpum; Scopolamine.

Figure 1

Effect of Morinda lucida on scopolamine induced memory impairment in Morris water maze test.

Figure 2

Effect of Peltophorum pterocarpum on scopolamine induced memory impairment mice in Morris Water maze test.

Figure 3

Histopathology of the hippocampus of mice treated with M. lucida

Figure 4

Histopathology of the hippocampus of mice treated with P. pterocarpum

Figure 5

Histopathology of the hippocampus of mice pretreated with 3 mg/kg Scopolamine Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg exhibited significant gradual improvement in memory and cognition.