Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Mar 1;14(3):136-141.
doi: 10.21010/ajtcam.v14i3.14. eCollection 2017.

COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE

Elufioye Taiwo O  1 , Hameed Halimah A  1
Affiliations

COGNITIVE-ENHANCING PROPERTIES OF MORINDA LUCIDA (RUBIACEAE) AND PELTOPHORUM PTEROCARPUM (FABACEAE) IN SCOPOLAMINE-INDUCED AMNESIC MICE

Elufioye Taiwo O et al. Afr J Tradit Complement Altern Med. .

Abstract

Background: Cognitive disorders associated with aging have been successfully managed by African traditional medical practitioners using various plants. This study evaluated the cognitive enhancing potentials of Morinda lucida (L) Rubiaceae and Peltophorum pterocarpum (DC) ex. K Heyne in scopolamine induced amnesic animals.

Materials and methods: The anti-amnesic activity of the ethyl acetate extracts of Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg were assessed in scopolamine induced amnesic mice using Morris water maze test model. Effect of the extracts on the histology of the hippocampus was also evaluated.

Results: The ethyl acetate extract of Morinda lucida and Peltophorum pterocarpum ameliorated scopolamine induced memory deficit in the animals under study. There was no effect of the extract on the histology of the hippocampus. However, there was an increase in the density of cells in the hippocampus of treated group as compared to the untreated.

Conclusion: Morinda lucida and Peltophorum pterocarpum showed considerable enhancement of cognition in scopolamine induced amnesic mice.

Keywords: Hippocampus; Morinda lucida; Morris water maze; Peltophorum pterocarpum; Scopolamine.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Effect of Morinda lucida on scopolamine induced memory impairment in Morris water maze test.
Figure 2
Figure 2
Effect of Peltophorum pterocarpum on scopolamine induced memory impairment mice in Morris Water maze test.
Figure 3
Figure 3
Histopathology of the hippocampus of mice treated with M. lucida
Figure 4
Figure 4
Histopathology of the hippocampus of mice treated with P. pterocarpum
Figure 5
Figure 5
Histopathology of the hippocampus of mice pretreated with 3 mg/kg Scopolamine Morinda lucida and Peltophorum pterocarpum at doses of 4 mg/kg, 6 mg/kg and 8 mg/kg exhibited significant gradual improvement in memory and cognition.
See this image and copyright information in PMC

References

    1. Auld D. S, Kornecook T. J, Bastianetto S, Quirion R. Alzheimer’s disease and the basal forebrain cholinergic system: relation to βamyloid peptides, cognition and treatment strategies. Progress in neurobiology. 2002;68(3):209–245. - PubMed
    1. Bejar C, Wang R. H, Weinstock M. Effect of rivastigmine on scopolamine-induced memory impairment in rats. Europrean Journal of Pharmacology. 1999;383:231–240. - PubMed
    1. Broks P, Preston G. C, Traub M, Poppleton P, Ward C, Stahl S. M. Modelling dementia: effects of scopolamine on memory and attention. Neuropsychologia. 1988;26(5):685–700. - PubMed
    1. Buckner R. L. Memory and executive function in aging and AD: Multiple factors that cause decline and reverse factors than compensate. Neuron. 2004;44(1):195–208. - PubMed
    1. Elufioye T. O, Obuotor E. F, Agbedahunsi J. M, Adesanya S. A. Cholinesterase inhibitory activity of Morinda lucida benth. Journal of Pharmacognosy and phytotherapy. 2013;5:77–82.

LinkOut - more resources