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Meta-Analysis
. 2018 Mar 4;14(3):724-735.
doi: 10.1080/21645515.2017.1321722. Epub 2017 Jun 16.

Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies

Vincenzo Restivo  1 , Claudio Costantino  1 , Stefania Bono  1 , Marialuisa Maniglia  1 , Valentina Marchese  1 , Gianmarco Ventura  1 , Alessandra Casuccio  1 , Fabio Tramuto  1 , Francesco Vitale  1
Affiliations
Meta-Analysis

Influenza vaccine effectiveness among high-risk groups: A systematic literature review and meta-analysis of case-control and cohort studies

Vincenzo Restivo et al. Hum Vaccin Immunother. .

Abstract

Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For 3 high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was performed. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32-46%) for visits and 57% (95%CI: 30-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6-40%) for visits and 14% (95%CI: 7-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes.

Keywords: children; chronic disease; effectiveness; elderly subjects; health care worker; hospitalization; influenza; pregnancy; vaccine; visit.

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Figures

Figure 1.
Figure 1.
Flowchart of the systematic literature review process about influenza vaccine effectiveness among high risk groups.
Figure 2.
Figure 2.
Forest plot of influenza visits and hospitalization vaccine effectiveness (1-Odds ratio) among children from 6 months to 18 year old.
Figure 3.
Figure 3.
Forest plot of influenza visits and hospitalization vaccine effectiveness (1-Odds ratio) among elderly subjects.
See this image and copyright information in PMC

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