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. 1988 Dec;85(23):9297-301.
doi: 10.1073/pnas.85.23.9297.

Stress-induced alterations of immunity in hypophysectomized rats

S E Keller  1 , S J Schleifer, A S Liotta, R N Bond, N Farhoody, M Stein
Affiliations

Stress-induced alterations of immunity in hypophysectomized rats

S E Keller et al. Proc Natl Acad Sci U S A. 1988 Dec.

Abstract

Stress-induced suppression of mitogen-induced lymphocyte proliferation was demonstrated in hypophysectomized rats. Stress effects on the numbers of peripheral blood lymphocytes and lymphocyte subsets and on splenic natural killer cell activity require the presence of pituitary. A pituitary-dependent restraining influence on stress-induced alteration of immunity is described. These results indicate that stress-induced modulation of immunity is complex and includes a range of enhancing and inhibitory mechanisms.

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References

    1. Scand J Haematol. 1973;11(4):275-86 - PubMed
    1. Ciba Found Symp. 1986;123:191-215 - PubMed
    1. J Immunol. 1977 Jul;119(1):98-103 - PubMed
    1. Nature. 1977 Dec 15;270(5638):618-20 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2950-4 - PubMed