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. 2017 May 8;17(1):109.
doi: 10.1186/s12872-017-0533-2.

Very early recurrence predicts long-term outcome in patients after atrial fibrillation catheter ablation: a prospective study

Yangjing Xue  1 , Xiaoning Wang  2 , Saroj Thapa  1 , Luping Wang  3 , Jiaoni Wang  1 , Zhiqiang Xu  1 , Shaoze Wu  1 , Luyuan Tao  1 , Guoqiang Wang  1 , Lu Qian  1 , Lianming Liao  4 , Baohua Liu  5 , Kangting Ji  6
Affiliations

Very early recurrence predicts long-term outcome in patients after atrial fibrillation catheter ablation: a prospective study

Yangjing Xue et al. BMC Cardiovasc Disord. .

Abstract

Background: Long-term recurrence (LR) is a tendency that re-occurs within 3 months after catheter ablation for atrial fibrillation (AF). Whether very early recurrence (VER) within 7 days of post ablation is a prognostic factor of LR or not is unclear. For this reason, present study sought to examine the relationship between VER and LR.

Methods: In this prospective analysis 378 consecutive patients underwent an initial catheter ablation for paroxysmal or persistent AF. The association between VER and LR was analyzed by univariate and multivariate Cox regression, as well as time-dependent receiver operator characteristic (ROC) analysis.

Results: After a mean follow-up of 14.71 ± 8.58 months, 81 (65.90%) patients with VER experienced LR and were associated with lower event of free survival from LR (Log rank test, P < 0.001). Multivariate Cox regression analysis revealed that VER (HR = 7.02, 95% CI = 4.78-10.31; P < 0.001), left atrial enlargement (HR = 2.92, 95% CI = 1.88-4.54; P < 0.001), tendency in advanced age (HR = 1.50, 95% CI = 0.99-2.28; P = 0.054), and tendency in male (HR = 0.71, 95% CI = 0.50-1.01; P = 0.060) were independent predictors of LR. According to time-dependent ROC analysis, it was found that VER was more sensitive than common risk factors in predicting LR (0.74 vs 0.66, P < 0.001) and combination model further improved the C statistic for predicting LR (0.82 vs 0.66, P < 0.001).

Conclusions: After a single procedure of catheter ablation, patients with VER were strongly associated with LR and combination of VER and common risk factors could further improve prediction of patients who were at high risk for LR.

Keywords: Atrial fibrillation; Catheter ablation; Long-term recurrence; Very early recurrence.

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Figures

Fig. 1
Fig. 1
Relationship between very early recurrence (VER) and long-term recurrence (LR). In patients without LR, the constitution of VER was of 12.20%; In patients with LR, the constitution of VER was of 65.90%
Fig. 2
Fig. 2
Event-free survival from the long-term recurrence (LR) for patients with and without very early recurrence (VER)
Fig. 3
Fig. 3
Time-dependent ROC analysis based on very early recurrence (VER) and established common risk factors (0.74 vs 0.66, P < 0.001), respectively
Fig. 4
Fig. 4
Time-dependent ROC analysis based on combined model and established common risk factors (0.82 vs 0.66, P < 0.001)
See this image and copyright information in PMC

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