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Randomized Controlled Trial
. 2017 May 8;17(1):253.
doi: 10.1186/s12906-017-1741-0.

The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial

Aliasghar Kheiri  1 , Shahideh Amini  2 , Abbas Norouzi Javidan  3 , Mohammad Mehdi Saghafi  4 , Ghasemali Khorasani  5
Affiliations
Randomized Controlled Trial

The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial

Aliasghar Kheiri et al. BMC Complement Altern Med. .

Abstract

Background: A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft.

Methods: Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2nd and 4th weeks after intervention.

Results: Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively.

Conclusions: This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.

Trial registration: IRCT ID: IRCT201511165781N2 .

Keywords: Alkanna; Healing; Skin graft; Wound.

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Figures

Fig. 1
Fig. 1
Consort flowchart of the study.*Seven diabetic patients, three patients with chronic kidney disease and five patients who were unwilling to participate in the study were excluded
See this image and copyright information in PMC

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