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Case Reports
. 2017 May 8;11(1):129.
doi: 10.1186/s13256-017-1290-7.

Adrenaline overdose in pediatric anaphylaxis: a case report

Pui Yi Lily Liew  1   2 , John Andrew Craven  3
Affiliations
Case Reports

Adrenaline overdose in pediatric anaphylaxis: a case report

Pui Yi Lily Liew et al. J Med Case Rep. .

Abstract

Background: Adrenaline is the standard treatment for anaphylaxis but appropriate administration remains challenging, and iatrogenic overdose is easily overlooked. Despite the established importance of pediatric blood pressure measurement, its use remains inconsistent in clinical practice.

Case presentation: We report a case of adrenaline overdose in a 9-year-old white boy with anaphylaxis, where signs of adrenaline overdose were indistinguishable from progressive shock until blood pressure measurement was taken.

Conclusions: The consequences of under-dosing adrenaline in anaphylaxis are well-recognized, but the converse is less so. Blood pressure measurement should be a routine part of pediatric assessment as it is key to differentiating adrenaline overdose from anaphylactic shock.

Keywords: Adrenaline; Anaphylaxis; Blood pressure; Case report; Children; Epinephrine; Overdose; Pediatric.

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References

    1. Simons FE, Ardusso LRF, Bilò MB, et al. World Allergy Organization guidelines for the assessment and management of anaphylaxis. World Allergy Organ J. 2011;4(2):13–37. doi: 10.1097/WOX.0b013e318211496c. - DOI - PMC - PubMed
    1. Australian Society of Clinical Immunology and Allergy. Guidelines: ADVANCED acute management of anaphylaxis. 2016. https://www.allergy.org.au/health-professionals. Accessed 20 Apr 2017.
    1. Kirkbright SJ, Brown SGA. Anaphylaxis: recognition and management. Aust Fam Physician. 2012;41(6):366–70. - PubMed
    1. Mullins RJ, Dear KB, Tang ML. Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. J Allergy Clin Immunol. 2015;136(2):367–75. doi: 10.1016/j.jaci.2015.05.009. - DOI - PubMed
    1. Liew WK, Williamson E, Tang MI. Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol. 2009;123:434–42. doi: 10.1016/j.jaci.2008.10.049. - DOI - PubMed

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