Review

. 2017 Aug;104(2):704-711.

doi: 10.1016/j.athoracsur.2017.01.114. Epub 2017 May 6.

De Novo Aortic Regurgitation After Continuous-Flow Left Ventricular Assist Device Implantation

Hrvoje Gasparovic¹, Tomislav Kopjar², Diyar Saeed³, Maja Cikes⁴, Lucija Svetina², Mate Petricevic², Daniel Lovric⁴, Davor Milicic⁴, Bojan Biocina²

Affiliations

¹ Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address: hgasparovic@gmail.com.
² Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
³ Clinic for Cardiovascular Surgery, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
⁴ Department of Cardiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.

PMID: 28483150
DOI: 10.1016/j.athoracsur.2017.01.114

Review

De Novo Aortic Regurgitation After Continuous-Flow Left Ventricular Assist Device Implantation

Hrvoje Gasparovic et al. Ann Thorac Surg. 2017 Aug.

. 2017 Aug;104(2):704-711.

doi: 10.1016/j.athoracsur.2017.01.114. Epub 2017 May 6.

Authors

Hrvoje Gasparovic¹, Tomislav Kopjar², Diyar Saeed³, Maja Cikes⁴, Lucija Svetina², Mate Petricevic², Daniel Lovric⁴, Davor Milicic⁴, Bojan Biocina²

Affiliations

¹ Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia. Electronic address: hgasparovic@gmail.com.
² Department of Cardiac Surgery, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
³ Clinic for Cardiovascular Surgery, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
⁴ Department of Cardiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.

PMID: 28483150
DOI: 10.1016/j.athoracsur.2017.01.114

Abstract

Continuous-flow left ventricular assist devices (cf-LVAD) play an important role in the management of patients with advanced heart failure. De novo aortic regurgitation after cf-LVAD implantation may adversely impact device performance. We performed a systematic search of PubMed, SCOPUS, and Cochrane Library for articles reporting on the incidence and predictors of de novo aortic regurgitation among cf-LVAD recipients. Eight studies totaling 548 patients were identified in the meta-analysis. The pooled incidence of de novo AR across the analyzed studies was 37%. Factors influencing its development and progression are older age, persistent aortic valve closure, being female, and duration of cf-LVAD support.

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De Novo Aortic Regurgitation After Continuous-Flow Left Ventricular Assist Device Implantation

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