Positive Skin Test or Specific IgE to Penicillin Does Not Reliably Predict Penicillin Allergy

Abstract

Introduction: According to guidelines, patients are diagnosed with penicillin allergy if skin test (ST) result or specific IgE (s-IgE) to penicillin is positive. However, the true sensitivity and specificity of these tests are presently not known.

Objective: To investigate the clinical relevance of a positive ST result and positive s-IgE and to study the reproducibility of ST and s-IgE.

Methods: A sample of convenience of 25 patients with positive penicillin ST results, antipenicillin s-IgE results, or both was challenged with their culprit penicillin. Further 19 patients were not challenged, but deemed allergic on the basis of a recent anaphylactic reaction or delayed reactions to skin testing. Another sample of convenience of 18 patients, 17 overlapping with the 25 challenged, with initial skin testing and s-IgE (median, 25; range, 3-121), months earlier (T_-1), was repeat skin tested and had s-IgE measured (T₀), and then skin tested and had s-IgE measured 4 weeks later (T₁).

Results: Only 9 (36%) of 25 were challenge positive. There was an increased probability of being penicillin allergic if both ST result and s-IgE were positive at T₀. Positive ST result or positive s-IgE alone did not predict penicillin allergy. Among the 18 patients repeatedly tested, 46.2% (12 of 25) of positive ST results at T_-1 were reproducibly positive at T₀. For s-IgE, 54.2% (14 of 24) positive measurements were still positive at T₀ and 7 converted to positive at T₁.

Conclusions: The best predictor for a clinically significant (IgE-mediated) penicillin allergy is a combination of a positive case history with simultaneous positive ST result and s-IgE or a positive challenge result.

Keywords: Penicillin allergy; Penicillin challenge; Skin test reproducibility; Specific IgE to penicillin reproducibility.