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Comment
. 2017 Jun;42(6):408-410.
doi: 10.1016/j.tibs.2017.04.002. Epub 2017 May 5.

Most Alternative Isoforms Are Not Functionally Important

Michael L Tress  1 , Federico Abascal  2 , Alfonso Valencia  3
Affiliations
Comment

Most Alternative Isoforms Are Not Functionally Important

Michael L Tress et al. Trends Biochem Sci. 2017 Jun.
No abstract available

Keywords: alternative splicing; biological complexity; mass spectrometry; selection.

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References

    1. Tress ML et al. Alternative splicing may not be the key to proteome complexity. Trends Biochem. 2017; 42: 98–110 - PMC - PubMed
    1. Blencowe B The relationship between alternative splicing and proteomic complexity. Trends Biochem. 2017; 00 (000–000). - PubMed
    1. Ezkurdia I et al. (2015) Most highly expressed protein-coding genes have a single dominant isoform. J. Proteome Res 14, 1880–1887 - PMC - PubMed
    1. Gonzàlez-Porta M et al. (2013) Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene. Genome Biol. 14, R70. - PMC - PubMed
    1. Hayer KE et al. (2015) Benchmark analysis of algorithms for determining and quantifying full-length mRNA splice forms from RNA-seq data. Bioinformatics 31, 3938–3945 - PMC - PubMed

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