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Clinical Trial
. 1988 Jun;28(6):527-9.

[Oral vaccination with live attenuated rotavirus]

[Article in Spanish]
H Escobar Castro  1 , M Perdomo Giraldi, A Tamáriz-Martel Moreno, L Suárez Cortina
Affiliations
  • PMID: 2848432
Clinical Trial

[Oral vaccination with live attenuated rotavirus]

[Article in Spanish]
H Escobar Castro et al. An Esp Pediatr. 1988 Jun.

Abstract

A randomized, double-blind trial was performed to assess serological response and clinical protection for acute gastroenteritis due to rotavirus in 103 children aged 6 to 18 months, after a single dose of RIT 4237 live attenuated bovine rotavirus vaccine or placebo. Seroconversion, determined by enzyme-linked immunoabsorbent assay (ELISA), was significantly greater in initially seronegative vaccines compared with control group (p less than 0.0001); clinical protection rate was low in this study group and it is therefore concluded that seroconversion by itself is not sufficient to measure vaccine efficacy.

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