doi: 10.1111/j.1749-6632.1988.tb22258.x.
Regulation of oocyte maturation. The role of cAMP
Affiliations
- PMID: 2848437
- DOI: 10.1111/j.1749-6632.1988.tb22258.x
Item in Clipboard
Regulation of oocyte maturation. The role of cAMP
Ann N Y Acad Sci.
1988.
Abstract
We suggest that cAMP is a key molecule in regulation of oocyte maturation. In the small follicle, tonic levels of cAMP are continuously transferred to the oocytes to maintain meiotic arrest. In the preovulatory follicle, in response to LH, cAMP levels are elevated. These increased concentrations of the nucleotide affect the cumulus cells and interrupt communication in the cumulus-oocyte complex. Under these conditions the flow of cAMP to the oocyte declines, inhibition is relieved, and meiosis is resumed.
Similar articles
-
Dissociation between the inhibitory and the stimulatory action of cAMP on maturation of rat oocytes.Mol Cell Endocrinol. 1988 Mar;56(1-2):115-21. doi: 10.1016/0303-7207(88)90015-9. Mol Cell Endocrinol. 1988. PMID: 2453385
-
Regulation of oocyte maturation: communication in the rat cumulus-oocyte complex.Hum Reprod. 1988 Aug;3(6):761-6. doi: 10.1093/oxfordjournals.humrep.a136780. Hum Reprod. 1988. PMID: 2464614
-
Meiotic arrest in incompetent rat oocytes is not regulated by cAMP.Dev Biol. 1994 Nov;166(1):11-7. doi: 10.1006/dbio.1994.1293. Dev Biol. 1994. PMID: 7958438
-
[In vitro maturation of mammalian oocytes. I. The hormonal regulation of maturation].Ontogenez. 1982;13(1):3-17. Ontogenez. 1982. PMID: 6278377 Review. Russian.
-
Stops and starts in mammalian oocytes: recent advances in understanding the regulation of meiotic arrest and oocyte maturation.Reproduction. 2005 Dec;130(6):791-9. doi: 10.1530/rep.1.00793. Reproduction. 2005. PMID: 16322539 Review.
Cited by
-
Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes.Reprod Biol Endocrinol. 2022 Feb 24;20(1):37. doi: 10.1186/s12958-022-00906-5. Reprod Biol Endocrinol. 2022. PMID: 35209923 Free PMC article. Review.
-
Cumulus cell contact during oocyte maturation in mice regulates meiotic spindle positioning and enhances developmental competence.J Assist Reprod Genet. 2010 Jan;27(1):29-39. doi: 10.1007/s10815-009-9376-9. Epub 2009 Dec 29. J Assist Reprod Genet. 2010. PMID: 20039198 Free PMC article.
-
Treatment variables in relation to oocyte maturation: lessons from a clinical micromanipulation-assisted in vitro fertilization program.J Assist Reprod Genet. 1997 Jul;14(6):337-42. doi: 10.1007/BF02765838. J Assist Reprod Genet. 1997. PMID: 9226513 Free PMC article.
-
Reconstruction of cell lineage trees in mice.PLoS One. 2008 Apr 9;3(4):e1939. doi: 10.1371/journal.pone.0001939. PLoS One. 2008. PMID: 18398465 Free PMC article.
-
Novel signaling mechanisms in the ovary during oocyte maturation and ovulation.Mol Cell Endocrinol. 2012 Jun 5;356(1-2):65-73. doi: 10.1016/j.mce.2011.11.002. Epub 2011 Nov 12. Mol Cell Endocrinol. 2012. PMID: 22101318 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
