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. 2017 May 8;31(5):609-611.
doi: 10.1016/j.ccell.2017.04.008.

Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Milan G Chheda  1 , David H Gutmann  2
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Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer

Milan G Chheda et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Nagaraja et al. dissect the molecular mechanisms underlying therapeutic responses to transcriptional disruptors in the fatal pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG). Moreover, they identify super-enhancers mediating these effects, highlighting how normal brain developmental programs can be hijacked in cancer.

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  • Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma.
    Nagaraja S, Vitanza NA, Woo PJ, Taylor KR, Liu F, Zhang L, Li M, Meng W, Ponnuswami A, Sun W, Ma J, Hulleman E, Swigut T, Wysocka J, Tang Y, Monje M. Nagaraja S, et al. Cancer Cell. 2017 May 8;31(5):635-652.e6. doi: 10.1016/j.ccell.2017.03.011. Epub 2017 Apr 20. Cancer Cell. 2017. PMID: 28434841 Free PMC article.

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