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Comment
. 2017 May 8;31(5):612-613.
doi: 10.1016/j.ccell.2017.04.011.

The Tribble with APL: A New Road to Therapy

Ruaidhrí Carmody  1 , Karen Keeshan  2
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Free article
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The Tribble with APL: A New Road to Therapy

Ruaidhrí Carmody et al. Cancer Cell. .
Free article

Abstract

The t(15;17) translocation generates a PML-RARα fusion protein causative for acute promyelocytic leukemia (APL). Li et al. now identify the pseudokinase stress protein TRIB3 as an important factor in APL disease progression and therapy resistance. Targeting the interaction of TRIB3 and PML-RARα using peptide technology provides a novel therapeutic approach.

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