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. 1988 Dec 5;241(1-2):209-12.
doi: 10.1016/0014-5793(88)81063-9.

Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung

S M Kanse  1 , B Kreymann, M A Ghatei, S R Bloom
Affiliations
Free article

Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung

S M Kanse et al. FEBS Lett. .
Free article

Abstract

High-affinity binding sites for glucagon-like peptide-1 7-36 amide (GLP-1 7-36 NH2) were identified in rat brain and lung membranes. Binding of [125I]GLP-1 7-36 NH2 was rapid, reversible, specific, saturable and pH dependent. Specific binding in the central nervous system was particularly high in the hypothalamus and the brain stem. Oxyntomodulin, glucagon-like peptide-1, glucagon-like peptide-2 and glucagon were 100-1000-fold less potent than GLP-1 7-36 NH2 in competition for this binding site.

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