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Clinical Trial
. 2017 Jun;15(1-2):13-18.
doi: 10.3121/cmr.2017.1351. Epub 2017 May 9.

Incidence of Primary Biliary Cholangitis in a Rural Midwestern Population

Rajan Kanth  1 , Ram Babu Shrestha  2 , Indira Rai  3 , Jeffrey J VanWormer  4 , Praveen K Roy  5
Affiliations
Clinical Trial

Incidence of Primary Biliary Cholangitis in a Rural Midwestern Population

Rajan Kanth et al. Clin Med Res. 2017 Jun.

Abstract

Background: Primary biliary cholangitis (PBC) is a rare disease with incidence that varies with time and geography. Only two studies have assessed PBC incidence in the United States, with the most recent appearing over a decade ago. The objective of the present study was to assess PBC incidence in the United States in a more recent era.

Methods: The incidence of PBC was assessed in a population-based cohort in rural, Midwestern Wisconsin over two decades spanning from June 1992 through June 2011. Cases were initially identified in the electronic medical record and then manually verified for inclusion according to the American Association for the Study of Liver Disease criteria for PBC. Additional data were abstracted for verified cases.

Results: A total of 79 cases of PBC were identified over the 20-year period for an overall age- and sex-standardized incidence of 4.9 cases per 100,000 person-years. Incidence was higher in females, but changes over time were not significant. After a mean 7.3 years follow-up, all-cause mortality of those with PBC was 29%, and estimated 10-year survival was 76%.

Conclusions: The overall incidence of PBC in a Midwestern population of the United States has remained relatively stable over the last two decades. Patients have better prognosis, and the survival of PBC cases has improved.

Keywords: Incidence; Population-Based Study; Primary Biliary Cholangitis; Primary Biliary Cirrhosis.

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Figures

Figure 1
Figure 1
Age-standardized incidence rate of primary biliary cholangitis (PBC), stratified by gender, in 5-year time segments.
Figure 2
Figure 2
Kaplan-Meier survival estimates over 10-years for patient with primary biliary cholangitis (PBC).
See this image and copyright information in PMC

References

    1. Griffiths L, Dyson JK, Jones DE. The new epidemiology of primary biliary cirrhosis. Semin Liver Dis 2014;34:318–328. - PubMed
    1. Invernizzi P, Selmi C, Ranftler C, Podda M, Wesierska-Gadek J. Antinuclear antibodies in primary biliary cirrhosis. Semin Liver Dis 2005;25:298–310. - PubMed
    1. Triger DR, Berg PA, Rodes J. Epidemiology of primary biliary cirrhosis. Liver 1984;4:195– 200. - PubMed
    1. Bhandari BM, Bayat H, Rothstein KD. Primary biliary cirrhosis. Gastroenterol Clin North Am 2011;40:373–386. - PubMed
    1. Delgado JS, Vodonos A, Delgado B, Jotkowitz A, Rosenthal A, Fich A, Novack V. Primary biliary cirrhosis in Southern Israel: a 20 year follow up study. Eur J Intern Med 2012;23:e193–e198. - PubMed

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