Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 May 16;114(20):5069-5071.
doi: 10.1073/pnas.1705326114. Epub 2017 May 9.

Compass in the data ocean: Toward chronotherapy

Affiliations
Comment

Compass in the data ocean: Toward chronotherapy

Rikuhiro G Yamada et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Simplified numerical representation of Linné’s flower clock. A hypothetical flower A is represented with red petals, and flower B is represented with blue petals around a 24-h clock. The openness of flowers is indicated as −1 (closed), 0 (half-open), or 1 (open). The 2D vectors that contain elements of flower openness are displayed below the corresponding flowers. The two thick black arrows form a basis of the plane, and any arbitrary vector of flower openness locates on the unit circle on the plane. A thin black vector is depicted as an example, and its phase (the time of day) is recapitulated as the angle between the axis and the vector (double arc). The yellow and black bands around the clock represent the day and night times of a day. In an actual situation, the dimension of the vector will be the number of biological molecules used in the analysis, or the number of nodes in the previous layer of the neural network.

Comment on

References

    1. Wright KP, Jr, Gronfier C, Duffy JF, Czeisler CA. Intrinsic period and light intensity determine the phase relationship between melatonin and sleep in humans. J Biol Rhythms. 2005;20:168–177. - PMC - PubMed
    1. Horowitz TS, Cade BE, Wolfe JM, Czeisler CA. Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work. Am J Physiol Endocrinol Metab. 2001;281:E384–E391. - PubMed
    1. Roenneberg T, Allebrandt KV, Merrow M, Vetter C. Social jetlag and obesity. Curr Biol. 2012;22:939–943. - PubMed
    1. Wulff K, Gatti S, Wettstein JG, Foster RG. Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease. Nat Rev Neurosci. 2010;11:589–599. - PubMed
    1. Ukai H, Ueda HR. Systems biology of mammalian circadian clocks. Annu Rev Physiol. 2010;72:579–603. - PubMed

Publication types

LinkOut - more resources