Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr 25:8:681.
doi: 10.3389/fmicb.2017.00681. eCollection 2017.

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

Mohammad J Nasiri  1 , Mehri Haeili  2 , Mona Ghazi  1 , Hossein Goudarzi  1 , Ali Pormohammad  1 , Abbas A Imani Fooladi  3 , Mohammad M Feizabadi  4   5
Affiliations
Review

New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria

Mohammad J Nasiri et al. Front Microbiol. .

Abstract

Infectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least isoniazid (INH) and rifampicin (RIF), two key drugs in the treatment of the disease. Despite the availability of curative anti-TB therapy, inappropriate and inadequate treatment has allowed MTB to acquire resistance to the most important anti-TB drugs. Likewise, for most mycobacteria other than MTB, the outcome of drug treatment is poor and is likely related to the high levels of antibiotic resistance. Thus, a better knowledge of the underlying mechanisms of drug resistance in mycobacteria could aid not only to select the best therapeutic options but also to develop novel drugs that can overwhelm the existing resistance mechanisms. In this article, we review the distinctive mechanisms of antibiotic resistance in mycobacteria.

Keywords: Mycobacterium; Nontuberculous mycobacteria; drug resistance; resistance; tuberculosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mechanisms of action of antimicrobial drugs and ways by which mycobacteria become resistant to them.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ahn J. W. (2013). Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis. J. Microbiol. Biotechnol. 23, 1529–1535. 10.4014/jmb.1306.06048 - DOI - PubMed
    1. Aínsa J. A., Blokpoel M. C., Otal I., Young D. B., De Smet K. A., Martín C. (1998). Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis. J. Bacteriol. 180, 5836–5843. - PMC - PubMed
    1. Alderwick L. J., Harrison J., Lloyd G. S., Birch H. L. (2015). The Mycobacterial cell wall—peptidoglycan and Arabinogalactan. Cold Spring Harb. Perspect. Med. 5:a021113. 10.1101/cshperspect.a021113 - DOI - PMC - PubMed
    1. Andini N., Nash K. A. (2006). Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible. Antimicrob. Agents Chemother. 50, 2560–2562. 10.1128/AAC.00264-06 - DOI - PMC - PubMed
    1. Andries K., Verhasselt P., Guillemont J., Göhlmann H. W., Neefs J.-M., Lee E. (2005). A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223–227. 10.1126/science.1106753 - DOI - PubMed

LinkOut - more resources