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Meta-Analysis
. 2016 Aug 12;13(5):160-169.
doi: 10.21010/ajtcam.v13i5.21. eCollection 2016.

TRADITIONAL CHINESE MEDICINE COMBINED WITH HORMONE THERAPY TO TREAT PREMATURE OVARIAN FAILURE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Mei-Jing Kou  1   2 , Xiu-Fang Ding  1 , Jia-Xu Chen  1   2 , Yan Liu  2 , Yue-Yun Liu  1
Affiliations
Meta-Analysis

TRADITIONAL CHINESE MEDICINE COMBINED WITH HORMONE THERAPY TO TREAT PREMATURE OVARIAN FAILURE: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Mei-Jing Kou et al. Afr J Tradit Complement Altern Med. .

Abstract

Background: This meta-analysis aimed to provide critically estimated evidence for the advantages and disadvantages of Chinese herbal medicines used for premature ovarian failure (POF), which could provide suggestions for rational treatments.

Materials and methods: The databases searched included MEDLINE, EMBASE, CNKI, VIP, China Dissertation Database, China Important Conference Papers Database, and online clinical trial registry websites. Published and unpublished randomized controlled trials of traditional Chinese medicine (TCM) combined with hormone therapy (HT) and HT alone for POF were assessed up to December 30, 2015. Two authors extracted data and assessed trial quality independently using Cochrane systematic review methods. Meta-analysis was used to quantitatively describe serum hormone levels and Kupperman scores associated with perimenopause symptoms.

Results: Seventeen randomized controlled trials involving 1352 participants were selected. Compared with HT alone, although no significant effects were observed in the levels of luteinizing hormone, therapy with TCM combined with HT compared to HT alone effectively altered serum hormone levels of follicle stimulating hormone (P<0.01) and estradiol (P < 0.01), and improved Kupperman index scores (P< 0.01).

Conclusions: The reported favorable effects of TCM combined with HT for treating POF patients are better than HT alone.However, the beneficial effects derived from this combination therapy cannot be viewed conclusive. In order to better support the clinical use, more rigorously designed trials are required to provide.

Keywords: Hormone therapy; Meta-analysis; Premature ovarian failure; Traditional Chinese medicine.

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Conflict of interest statement

Conflict of interest The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of activity
Figure 3
Figure 3
Comparisons of treatment efficacy between traditional Chinese medicine combined with hormone therapy and hormone therapy alone on FSH levels.
Figure 4
Figure 4
Comparisons of treatment efficacy between traditional Chinese medicine combined with hormone therapy and hormone therapy alone on LH levels.
Figure 5
Figure 5
Comparisons of treatment efficacy between traditional Chinese medicine combined with hormone therapy and hormone therapy alone on E2 levels.
Figure 6
Figure 6
Comparisons of treatment efficacy between traditional Chinese medicine combined with hormone therapy and hormone therapy alone on Kupperman scores.
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