Humoral factors in inflammatory disorders of the central and peripheral nervous system

Abstract

The immune-mediated disorders of the central and peripheral nervous systems all involve humoral mechanisms in which immunoglobulin, complement and/or other mediators are implicated. The disorders can be characterized by pattern of disease activity, site of immunoglobulin synthesis, humoral mechanism of injury, and presence of one or more concurrent cellular mechanisms of injury. Control of the humoral responses is presumably T-cell dependent. While these disorders should be viewed as having both humoral and cellular components, the specific components of each disorder might predict the response to specific therapeutic approaches.