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Case Reports
. 2017:21:16-060.
doi: 10.7812/TPP/16-060.

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Treatment With a Biologic: A Case Report

Ian Chong  1 , Alice Chao  2
Affiliations
Case Reports

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Treatment With a Biologic: A Case Report

Ian Chong et al. Perm J. 2017.

Abstract

Introduction: One of the most dangerous dermatologic emergencies is Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN). Although a rare disease, it can often lead to significant mortality.

Case presentation: In this case report, we present a 77-year-old man who developed a sloughing rash that was secondary to a nonsteroidal anti-inflammatory drug. In addition to the recommended supportive care, the patient was treated with etanercept, a new, less commonly used intervention.

Discussion: We provide a brief review of SJS/TEN. Nonsteroidal anti-inflammatory drugs are a rare cause of SJS/TEN, and additionally, the use of biologics is a novel treatment modality for SJS/TEN.

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Conflict of interest statement

Disclosure Statement

The author(s) have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Patient’s left forearm showing sloughing of skin. Patient had a positive Nikolsky sign.
Figure 2
Figure 2
Patient’s neck showing sloughing of skin.
Figure 3
Figure 3
Patient’s right wrist is dusky but without sloughing.
Figure 4
Figure 4
Timeline of the case. Derm = Dermatology Department; ED = Emergency Department; IM = Internal Medicine IV = intravenous; PO = orally; R = right; SJS = Stevens-Johnson Syndrome; TEN = toxic epidermal necrolysis.
Figure 5
Figure 5
Severity of illness score called SCORTEN (SCORe of Toxic Epidermal Necrolysis).
See this image and copyright information in PMC

References

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