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. 2017 May 24;139(20):6835-6838.
doi: 10.1021/jacs.7b03195. Epub 2017 May 10.

Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

Andrés García-Domínguez  1 , Zhaodong Li  1 , Cristina Nevado  1
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Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

Andrés García-Domínguez et al. J Am Chem Soc. .

Abstract

An intermolecular, three-component reductive dicarbofunctionalization of alkenes is presented here. The combination of Ni catalysis with TDAE as final reductant enables the direct formation of Csp3-Csp3 and Csp3-Csp2 bonds across a variety of π-systems using two different electrophiles that are sequentially activated with exquisite selectivity under mild reaction conditions.

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