Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Apr 27:13:575-582.
doi: 10.2147/TCRM.S125595. eCollection 2017.

Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients

Edyta Katarzyna Głażewska  1 , Marek Niczyporuk  1 , Sławomir Ławicki  2 , Maciej Szmitkowski  2 , Magdalena Donejko  1 , Monika Zajkowska  2 , Grażyna Ewa Będkowska  3 , Andrzej Przylipiak  1
Affiliations

Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients

Edyta Katarzyna Głażewska et al. Ther Clin Risk Manag. .

Abstract

Background: Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are thought to be associated with the pathogenesis and spread of psoriatic disease. This study was designed to investigate the plasma levels of MMP-3, MMP-9 and TIMP-3 in plaque psoriasis patients prior to and following a course of ultraviolet B narrowband treatment with respect to disease advancement.

Methods: Plasma samples of 49 patients suffering from plaque psoriasis and 40 healthy volunteers were evaluated. Concentrations of MMP-3, MMP-9 and TIMP-3 were determined using enzyme-linked immunosorbent assay, while Psoriasis Area and Severity Index was used to define disease advancement.

Results: Plasma levels of MMP-3, MMP-9 and TIMP-3 were significantly elevated in psoriasis patients compared to healthy individuals. A course of ultraviolet B narrowband treatment resulted in a significant decline in the studied metalloproteinases. Furthermore, the concentration of selected tissue inhibitors was negatively correlated with baseline Psoriasis Area and Severity Index score.

Conclusion: Our research highlights the meaningful role of MMP-3, MMP-9 and TIMP-3 in psoriasis pathogenesis and clearance of disease symptoms. Furthermore, plasma levels of the analyzed metalloproteinases seem to be a valuable psoriasis biomarker.

Keywords: gelatinase B; stromelysin 1.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Correlation of baseline plasma MMP-9 with baseline plasma TIMP-3 in patients with psoriasis. Abbreviations: MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase.
Figure 2
Figure 2
Correlation of posttreatment plasma MMP-9 with posttreatment plasma TIMP-3 in patients with psoriasis. Abbreviations: MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase.
Figure 3
Figure 3
Correlation of baseline plasma TIMP-3 with baseline PASI in patients with psoriasis. Abbreviations: PASI, Psoriasis Area And Severity Index; TIMP, tissue inhibitor of metalloproteinase.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Gooderham MJ, Poulin-Costello M, Shelton J, Bayan N, Papp KA. Predictors of topical use in psoriasis patients in the REFINE Study. J Cutan Med Surg. 2016;20(2):106–112. - PubMed
    1. Parisi R, Symmons DPM, Griffiths CEM, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013;133:377–385. - PubMed
    1. Cohen BE, Martires KJ, Ho RS. Psoriasis and the risk of depression in the US population: National Health and Nutrition Examination Survey 2009–2012. JAMA Dermatol. 2016;152(1):73–79. - PubMed
    1. Huerta C, Rivero E, Rodríguez LA. Incidence and risk factors for psoriasis in the general population. Arch Dermatol. 2007;143(12):1559–1565. - PubMed
    1. Boehncke WH. Etiology and pathogenesis of psoriasis. Rheum Dis Clin North Am. 2015;41(4):665–675. - PubMed