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Review
. 2017 Apr 27:9:265-272.
doi: 10.2147/IJWH.S129017. eCollection 2017.

Reproductive and hormonal risk factors of breast cancer: a historical perspective

Julie Horn  1   2 , Lars J Vatten  1
Affiliations
Review

Reproductive and hormonal risk factors of breast cancer: a historical perspective

Julie Horn et al. Int J Womens Health. .

Abstract

The complexity of breast cancer etiology has puzzled scientists for more than 300 years. In this brief review, we emphasize the importance of reproductive and hormonal factors in relation to the risk of breast cancer. By following the historical course of how various risk factors have been determined, this study attempts to illustrate the origin of hypotheses, their subsequent rejection, and development of new hypotheses. Starting with the contributions of Italian physicians in the 18th century and covering the activity of British epidemiologists before World War II, this review ends up with the international collaboration that became increasingly important in the second half of the 20th century.

Keywords: age at first birth; epidemiology; estrogen; lactation; parity; pregnancy.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

References

    1. Campbell H. A review of studies of breast cancer in human populations excluding endocrine studies. Proc R Soc Med. 1972;65(7):641–645. - PMC - PubMed
    1. Franco G, Franco F. Bernardino Ramazzini: the father of occupational medicine. Am J Public Health. 2001;91(9):1382. - PMC - PubMed
    1. Ramazzini B. De Mortis Artificum Diatriba The Latin Text of 1713, Rev with Translation and Notes by W. C. Wright. Chicago, IL: University of Chicago Press; 1940.
    1. Franco G. Bernardino Ramazzini and women workers’ health in the second half of the XVIIth century. J Public Health. 2012;34(2):305–308. - PubMed
    1. Mustacchi P. Ramazzini and Rigoni-Stern on parity and breast cancer. Clinical impression and statistical corroboration. Arch Intern Med. 1961;108:639–642. - PubMed

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