Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

Tristan Shuman¹, Benjamin Amendolara^{1

2

3}, Peyman Golshani^{1

4

5

6}

Affiliations

¹ Departments of Neurology and Psychiatry, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.
² UCLA Medical Scientist Training Program, Los Angeles, CA.
³ Neuroscience Interdepartmental Program, UCLA, Los Angeles, CA.
⁴ West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA.
⁵ Intellectual and Developmental Disability Research Center, UCLA, Los Angeles, CA.
⁶ Integrative Center for Learning and Memory, UCLA, Los Angeles, CA.

PMID: 28491003
PMCID: PMC5416857
DOI: 10.5698/1535-7511.17.2.107

Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

Tristan Shuman et al. Epilepsy Curr. 2017 Mar-Apr.

. 2017 Mar-Apr;17(2):107-111.

doi: 10.5698/1535-7511.17.2.107.

Authors

Tristan Shuman¹, Benjamin Amendolara^{1

2

3}, Peyman Golshani^{1

4

5

6}

Affiliations

¹ Departments of Neurology and Psychiatry, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA.
² UCLA Medical Scientist Training Program, Los Angeles, CA.
³ Neuroscience Interdepartmental Program, UCLA, Los Angeles, CA.
⁴ West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA.
⁵ Intellectual and Developmental Disability Research Center, UCLA, Los Angeles, CA.
⁶ Integrative Center for Learning and Memory, UCLA, Los Angeles, CA.

PMID: 28491003
PMCID: PMC5416857
DOI: 10.5698/1535-7511.17.2.107

Abstract

Memory difficulties are commonly associated with temporal lobe epilepsy (TLE) and cause significant disability. This article reviews the role of altered hippocampal theta oscillations and theta-gamma coupling as potential causes of memory disturbance in temporal lobe epilepsy, dissecting the potential mechanisms underlying these changes in large-scale neuronal synchronization. We discuss development of treatments for cognitive dysfunction directed at restoring theta rhythmicity and future directions for research.

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Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

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Theta Rhythmopathy as a Cause of Cognitive Disability in TLE

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