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Case Reports
. 2017 May 5:13:120-122.
doi: 10.1016/j.eucr.2017.04.001. eCollection 2017 Jul.

A 45,X/46,XY Male with Orchidopexy Diagnosed with Mixed Germ Cell Tumor After 21-year Follow-up

Masashi Kubota  1 , Naoki Terada  1 , Katsuhiro Ito  1 , Hideaki Takada  1 , Toshihiro Magaribuchi  1 , Atsuro Sawada  1 , Shusuke Akamatsu  1 , Hiromitsu Negoro  1 , Ryoichi Saito  1 , Takashi Kobayashi  1 , Toshinari Yamasaki  1 , Takahiro Inoue  1 , Osamu Ogawa  1
Affiliations
Case Reports

A 45,X/46,XY Male with Orchidopexy Diagnosed with Mixed Germ Cell Tumor After 21-year Follow-up

Masashi Kubota et al. Urol Case Rep. .

Abstract

A case of a 45,X/46,XY boy with gonadal dysgenesis is presented. The patient showed hypospadias and right undescended testis. He underwent underwent repair surgery for hypospadias, right orchidopexy, and bilateral testicular biopsy. Testicular biopsy revealed no malignant finding. He was followed-up annually by scrotum palpation. When the patient grew up to 24 years old, he was diagnosed to have right testicular tumor. High orchiectomy revealed pT1 seminoma. The management of undescended testis in men with gonadal dysgenesis and disordered sexual development is discussed.

Keywords: CT, computed tomography; DSD, disordered sexual development; Disordered sexual development; FSH, follicle-stimulating hormone; GCT, germ cell tumor; GD, gonadal dysgenesis; Gonadal dysgenesis; LH, luteinizing hormone; MRI, magnetic resonance imaging; Management; Orchiectomy; US, ultrasound.

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Figures

Figure 1
Figure 1
US findings of right testis. Arrows indicate the testicular tumor.
Figure 2
Figure 2
Magnetic resonance imaging findings. Images taken by T1WI (left) and T2WI (right). Arrows indicate the testicular tumor.
Figure 3
Figure 3
Microscopic findings (Hematoxylin–Eosin staining). Left image, seminoma; right image, teratoma.
See this image and copyright information in PMC

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