Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

doi:10.1016/j.ijwd.2015.08.002

Case Reports

. 2015 Oct 23;1(4):167-169.

doi: 10.1016/j.ijwd.2015.08.002. eCollection 2015 Dec.

Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Cassandra Chaptini¹, Genevieve Casey², Adam G Harris^{3

4}, David Wattchow¹, Lynne Gordon¹, Dedee F Murrell^{3

4}

Affiliations

¹ Flinders Medical Centre, Adelaide, Australia.
² Women's and Children's Hospital, Adelaide, Australia.
³ Department of Dermatology, St. George Hospital, Sydney, Australia.
⁴ Faculty of Medicine, University of New South Wales, Sydney, Australia.

PMID: 28491983
PMCID: PMC5419760
DOI: 10.1016/j.ijwd.2015.08.002

Case Reports

Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

Cassandra Chaptini et al. Int J Womens Dermatol. 2015.

. 2015 Oct 23;1(4):167-169.

doi: 10.1016/j.ijwd.2015.08.002. eCollection 2015 Dec.

Authors

Cassandra Chaptini¹, Genevieve Casey², Adam G Harris^{3

4}, David Wattchow¹, Lynne Gordon¹, Dedee F Murrell^{3

4}

Affiliations

¹ Flinders Medical Centre, Adelaide, Australia.
² Women's and Children's Hospital, Adelaide, Australia.
³ Department of Dermatology, St. George Hospital, Sydney, Australia.
⁴ Faculty of Medicine, University of New South Wales, Sydney, Australia.

PMID: 28491983
PMCID: PMC5419760
DOI: 10.1016/j.ijwd.2015.08.002

Abstract

We report a 20-year-old female with generalized, severe, recessive dystrophic epidermolysis bullosa who developed secondary chronic anal fissures. This resulted in anal sphincter spasm and severe, disabling pain. She was treated with five botulinum toxin A injections into the internal anal sphincter over a period of 2 years and gained marked improvement in her symptoms. This case demonstrates the successful use of botulinum toxin A injections to relieve anal sphincter spasm and fissuring, with long-term improvement.

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References

1. Abitbol R.J., Zhou L.H. Treatment of epidermolysis bullosa simplex, Weber-Cockayne type, with botulinum toxin type A. Arch Dermatol. 2009;145(1):13–15. - PubMed
1. Brisinda G., Albanese A., Cadeddu F., Bentivoglio A.R., Mabisombi A., Marniga G. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized "Botox vs. Dysport" controlled trial. Aliment Pharmacol Ther. 2004;19(6):695–701. - PubMed
1. Brisinda G., Cadeddu F., Brandara F., Marniga G., Maria G. Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. Br J Surg. 2007;94(2):162–167. - PubMed
1. Chaptini C., Casey G., Harris A.G., Murrell D.F., Gordon L. Recessive dystrophic epidermolysis bullosa complicated by secondary hepatic amyloidosis. JAAD Case Rep. 2015;1(6):337–339. - PMC - PubMed
1. Frew J.W., Martin L.K., Nijsten T., Murrell D.F. Quality of life evaluation in epidermolysis bullosa (EB) through the development of the QOLEB questionnaire: an EB-specific quality of life instrument. Br J Dermatol. 2009;61(6):1323–1330. - PubMed

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[1] Abitbol R.J., Zhou L.H. Treatment of epidermolysis bullosa simplex, Weber-Cockayne type, with botulinum toxin type A. Arch Dermatol. 2009;145(1):13–15. - PubMed

[2] Abitbol R.J., Zhou L.H. Treatment of epidermolysis bullosa simplex, Weber-Cockayne type, with botulinum toxin type A. Arch Dermatol. 2009;145(1):13–15. - PubMed

[3] Brisinda G., Albanese A., Cadeddu F., Bentivoglio A.R., Mabisombi A., Marniga G. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized "Botox vs. Dysport" controlled trial. Aliment Pharmacol Ther. 2004;19(6):695–701. - PubMed

[4] Brisinda G., Albanese A., Cadeddu F., Bentivoglio A.R., Mabisombi A., Marniga G. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized "Botox vs. Dysport" controlled trial. Aliment Pharmacol Ther. 2004;19(6):695–701. - PubMed

[5] Brisinda G., Cadeddu F., Brandara F., Marniga G., Maria G. Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. Br J Surg. 2007;94(2):162–167. - PubMed

[6] Brisinda G., Cadeddu F., Brandara F., Marniga G., Maria G. Randomized clinical trial comparing botulinum toxin injections with 0.2 per cent nitroglycerin ointment for chronic anal fissure. Br J Surg. 2007;94(2):162–167. - PubMed

[7] Chaptini C., Casey G., Harris A.G., Murrell D.F., Gordon L. Recessive dystrophic epidermolysis bullosa complicated by secondary hepatic amyloidosis. JAAD Case Rep. 2015;1(6):337–339. - PMC - PubMed

[8] Chaptini C., Casey G., Harris A.G., Murrell D.F., Gordon L. Recessive dystrophic epidermolysis bullosa complicated by secondary hepatic amyloidosis. JAAD Case Rep. 2015;1(6):337–339. - PMC - PubMed

[9] Frew J.W., Martin L.K., Nijsten T., Murrell D.F. Quality of life evaluation in epidermolysis bullosa (EB) through the development of the QOLEB questionnaire: an EB-specific quality of life instrument. Br J Dermatol. 2009;61(6):1323–1330. - PubMed

[10] Frew J.W., Martin L.K., Nijsten T., Murrell D.F. Quality of life evaluation in epidermolysis bullosa (EB) through the development of the QOLEB questionnaire: an EB-specific quality of life instrument. Br J Dermatol. 2009;61(6):1323–1330. - PubMed

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Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

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Botulinum toxin A injection for chronic anal fissures and anal sphincter spasm improves quality of life in recessive dystrophic epidermolysis bullosa

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