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Review
. 2016 Jul 18;2(3):77-84.
doi: 10.1016/j.ijwd.2016.05.001. eCollection 2016 Sep.

A dermatologist guide to immunogenicity

Collin M Blattner  1 , Soham P Chaudhari  2 , John Young 3rd  3 , Jenny E Murase  4   5
Affiliations
Review

A dermatologist guide to immunogenicity

Collin M Blattner et al. Int J Womens Dermatol. .

Abstract

Dermatologists should be aware that autoantibody formation may occur after the initiation of biologic therapy. This phenomenon has been referred to as immunogenicity and biologic fatigue. Because of this, patients may experience loss of clinical efficacy to a particular drug. To combat this phenomenon, low-dose immunomodulators may be used in hopes of preventing autoantibodies. We review the current literature and provide a basic treatment algorithm for patients with moderate to severe psoriasis.

Keywords: HACA antibodies; antidrug antibodies; autoantibodies; biologic fatigue; resistance to biologics.

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Figures

Fig. 1
Fig. 1
Basic treatment algorithm for moderate to severe psoriasis.
See this image and copyright information in PMC

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