Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Feb 16;3(1 Suppl):S1-S5.
doi: 10.1016/j.ijwd.2017.02.002. eCollection 2017 Mar.

Retrospective evidence on outcomes and experiences of pregnancy and childbirth in epidermolysis bullosa in Australia and New Zealand

Lizbeth R A Intong  1   2 , S Deanne Choi  1 , Alexa Shipman  1 , Yong C Kho  1   2 , Shelley J E Hwang  1   2 , Lesley M Rhodes  1   2 , Judie R Walton  3   2 , Michael G Chapman  4   2 , Dédée F Murrell  1   2
Affiliations

Retrospective evidence on outcomes and experiences of pregnancy and childbirth in epidermolysis bullosa in Australia and New Zealand

Lizbeth R A Intong et al. Int J Womens Dermatol. .

Abstract

Background: Pregnancy in epidermolysis bullosa (EB) has not been comprehensively studied.

Objective: We aimed to develop a foundational database, which could provide peri-obstetric advice in EB.

Methods: Survey questionnaires were sent to obstetricians, unaffected mothers of EB babies, and mothers with EB. Results were analyzed using chi-square, Fisher exact, and t-tests.

Results: Out of 1346 obstetricians surveyed, 195 responded, and only 14 had encountered EB. All recommended normal vaginal delivery (NVD), except for one elective Caesarean section (CS). We received responses from 75 unaffected mothers who had delivered EB babies. They had significantly more complications in their EB pregnancies compared to their non-EB pregnancies. A further 44 women with various types of EB who had given birth responded. Most delivered via NVD and had no significant increase in complications in both their EB and non-EB pregnancies. In both groups, there were no significant differences in blistering at birth in babies delivered via NVD and CS.

Conclusion: In conclusion, most patients with EB who are capable of giving birth do not have an increased risk for pregnancy-related complications and NVD appears to be safe. Awareness of this data amongst obstetricians and dermatologists should lead to improved quality of care for mothers and babies affected with EB.

Keywords: Anesthesia; Childbirth; Delivery; Epidermolysis Bullosa; Pregnancy.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Baloch M.S., Fitzwilliams B., Mellerio J., Lakasing L., Bewley S., O’Sullivan G. Anesthetic management of two different modes of delivery in patients with dystrophic epidermolysis bullosa. Int J Obstet Anesth. 2008;17:153–158. - PubMed
    1. Berryhill R.E., Benumof J.L., Saidman L.J., Smith P.C., Plumer M.H. Anesthetic management of emergency cesarean section in a patient with epidermolysis bullosa dystrophica polydysplastica. Anesth Analg. 1978;57:281–283. - PubMed
    1. Bianca S., Reale A., Ettore G. Pregnancy and caesarean delivery in a patient with dystrophic epidermolysis bullosa. Eur J Obstet Reprod Biol. 2003;110:235–236. - PubMed
    1. Broster T., Placek R., Eggers G.W.N., Jr. Epidermolysis bullosa: Anesthetic management for cesarean section. Anesth Analg. 1987;66:341–343. - PubMed
    1. Büscher U., Wessel J., Anton-Lamprecht I., Dudenhausen J.W. Pregnancy and delivery in a patient with mutilating dystrophic epidermolysis bullosa (Hallopeau-Siemens type) Obstet Gynecol. 1997;89:817–820. - PubMed