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. 2017 May 11;8(5):e92.
doi: 10.1038/ctg.2017.19.

Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing

Tara Maga  1 , Lara Balay  1 , Barbara Jung  1   2
Affiliations

Advantages and Some Remaining Challenges in Hereditary Gastrointestinal Cancer Panel Testing

Tara Maga et al. Clin Transl Gastroenterol. .

Abstract

Colorectal cancer affects 1 in 20 men and women in their lifetime. About 30% of these cases have been shown to be familial while only about 5% are associated with a highly penetrant hereditary colon cancer syndrome. In many familial cases, however, no mutation in the commonly implicated CRC genes is found. With the development of next-generation sequencing, testing laboratories are now able to offer hereditary gastrointestinal panel testing, which allows for the simultaneous sequencing of a much broader set of genes associated with CRC. We discuss the advantages and disadvantages of such testing to inform best clinical practice.

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Conflict of interest statement

Guarantor of the article: Barbara Jung, MD.

Specific author contributions: Conceived the study, finalized the manuscript and submitted the manuscript: B.J.; collected data and information and wrote the first draft of the manuscript: L.B.; collected information and contributed sections to the manuscript: T.M.

Financial support: None.

Potential competing interest: Dr Barbara Jung is accepting full responsibility for the conduct of the study and she has access to the data and has control of the decision to publish. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Clinical management recommendations based on the three possible results from genetic testing.
See this image and copyright information in PMC

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