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. 2017 Oct;82(4):596-606.
doi: 10.1038/pr.2017.118. Epub 2017 Jun 7.

Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study

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Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study

Maribel Casas et al. Pediatr Res. 2017 Oct.

Abstract

BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy obesity was associated with neuropsychological development in 1,827 Spanish children. At 5 years, cognitive and psychomotor development was assessed using McCarthy Scales of Children's Abilities, attention deficit hyperactivity disorder (ADHD) symptoms using the Criteria of Diagnostic and Statistical Manual of Mental Disorders, and autism spectrum disorder symptoms using the Childhood Asperger Syndrome Test. Models were adjusted for sociodemographic factors and maternal intelligence quotient. We used paternal obesity as negative control exposure as it involves the same source of confounding than maternal obesity.ResultsThe percentage of obese mothers and fathers was 8% and 12%, respectively. In unadjusted models, children of obese mothers had lower scores than children of normal weight mothers in all McCarthy subscales. After adjustment, only the verbal subscale remained statistically significantly reduced (β: -2.8; 95% confidence interval: -5.3, -0.2). No associations were observed among obese fathers. Maternal and paternal obesity were associated with an increase in ADHD-related symptoms. Parental obesity was not associated with autism symptoms.ConclusionMaternal pre-pregnancy obesity was associated with a reduction in offspring verbal scores at pre-school age.

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References

    1. J Child Psychol Psychiatry. 2010 Feb;51(2):134-43 - PubMed
    1. Obesity (Silver Spring). 2008 Aug;16(8):1809-15 - PubMed
    1. Am J Epidemiol. 2008 Jan 15;167(2):169-77 - PubMed
    1. Actas Esp Psiquiatr. 2001 Mar-Apr;29(2):95-102 - PubMed
    1. Int J Epidemiol. 2013 Apr;42(2):506-17 - PubMed

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