Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 May 11;12(5):e0177204.
doi: 10.1371/journal.pone.0177204. eCollection 2017.

Impact of treatment in long-term survival patients with follicular lymphoma: A Spanish Lymphoma Oncology Group registry

Mariano Provencio  1 , Pilar Sabín  2 , Jose Gomez-Codina  3 , Maria Torrente  1 , Virginia Calvo  1 , Marta Llanos  4 , Josep Gumá  5 , Cristina Quero  6 , Ana Blasco  7 , Miguel Angel Cruz  8 , David Aguiar  9 , Francisco García-Arroyo  10 , Javier Lavernia  11 , Natividad Martinez  12 , Manuel Morales  13 , Alvaro Saez-Cusi  14 , Delvys Rodriguez  15 , Luis de la Cruz  16 , Jose Javier Sanchez  17 , Antonio Rueda  18 ; GOTEL (Spanish Lymphoma Oncology Group)
Affiliations

Impact of treatment in long-term survival patients with follicular lymphoma: A Spanish Lymphoma Oncology Group registry

Mariano Provencio et al. PLoS One. .

Abstract

Background: Follicular lymphoma is the second most common non-Hodgkin lymphoma in the United States and Europe. However, most of the prospective randomized studies have very little follow-up compared to the long natural history of the disease. The primary aim of this study was to investigate the long-term survival of our series of patients with follicular lymphoma.

Patients and methods: A total of 1074 patients with newly diagnosed FL were enrolled. Patients diagnosed were prospectively enrolled from 1980 to 2013.

Results: Median follow-up was 54.9 months and median overall survival is over 20 years in our series. We analyzed the patients who are still alive beyond 10 years from diagnosis in order to fully assess the prognostic factors that condition this group. Out of 166 patients who are still alive after more than 10 years of follow-up, 118 of them (73%) are free of evident clinical disease. Variables significantly associated with survival at 10 years were stage < II (p <0.03), age < 60 years (p <0.0001), low FLIPI (p <0.002), normal β2 microglobulin (p <0.005), no B symptoms upon diagnosis (p <0.02), Performance Status 0-1 (p <0.03) and treatment with anthracyclines and rituximab (p <0.001), or rituximab (p <0.0001).

Conclusions: A longer follow-up and a large series demonstrated a substantial population of patients with follicular lymphoma free of disease for more than 10 years.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Overall survival (in months) according to performance status ECOG (B) and FLIPI score at diagnosis (C) for all patients (n = 1074).
Fig 2
Fig 2. Kaplan-Meier estimates of survival (in years) according to age (over or under 40 years of age).
Fig 3
Fig 3. Correlation between group of age and HR value, obtained by Cox model.
HR indicates hazard risk and R2explains the great correlation between HR and age, with less than a 5% error.
Fig 4
Fig 4. Adjusted death hazard rate to year of diagnosis for the Spanish Lymphoma Study.
See this image and copyright information in PMC

References

    1. Marcos-Gragera R, Gumà J, De Sanjose S. Análisis de la incidencia, la supervivencia y la mortalidad según las principales localizaciones tumorales, 1985–2019: linfomas no Hodgkin. Med Clin (Barc) 2008; 131 (Supl 1):72–77. - PubMed
    1. The Non-Hodgkin´s Lymphoma Classification Project: A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin´s lymphoma. Blood 1997; 89 (11): 3909–18. - PubMed
    1. Armitage JO, Weisenburger DD: New approach to classifying non-Hodgkin´s lymphomas: clinical features of the major histologic subtypes. J Clin Oncol 1998; 16:2780–95. 10.1200/JCO.1998.16.8.2780 - DOI - PubMed
    1. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H. et al. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: IARC; 2008. ISBN 9283224310. Pp. 200–226.
    1. Dreyling M, Guielmini M, Marcus R, Salles G,Vitolo U, Ladetto M, on behalf of the ESMO Guidelines Working Group. Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann of Oncol 2014; 25 (suppl 3): iii76–iii82 - PubMed

MeSH terms